Terbitop

Terbitop

Terbinafine is an antifungal medication that fights infections caused by fungus.Terbinafine tablets are used to treat infections caused by fungus that affect the fingernails or toenails.Terbinafine oral granules are used to treat a fungal infection of scalp hair follicles in children who are at least 4 years old.

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Composition : Terbinafine Tablets USP

Terbinafine is an antifungal medication that fights infections caused by fungus.Terbinafine tablets are used to treat infections caused by fungus that affect the fingernails or toenails.Terbinafine oral granules are used to treat a fungal infection of scalp hair follicles in children who are at least 4 years old.

Indications :

Terbinafine tablets are for the treatment of fungal infections of the skin and nails causedby TrichopytonMicrosporumcanis and Epidermophyton floccosum.

  1. Terbinafine tablets are indicated in the treatment of ringworm (tinea corporis, tinea cruris and tinea pedis) where oral therapy is considered appropriate due to the site, severity or extent of the infection.
  2. Terbinafine tablets are indicated in the treatment of onychomycosis.

 Contraindications :

Hypersensitivity to the active substance or to any of the followingexcipients :

Microcrystalline Cellulose, Croscarmellose Sodium, Anhydrous Colloidal Silica, Hypromellose and Magnesium Stearate.

Pharmacodynamics :

Terbinafine is an allylamine antifungal that inhibits squalene epoxidase (also known as squalene monooxygenase) to prevent the formation of ergosterol and cause an accumulation of squalene, weakening the cell wall of fungal cells.Terbinafine distributes into tissues and has a long terminal elimination half life, so the duration of action is long. Overdose with terbinafine is rare, even above the therapeutic dose, so the therapeutic index is wide.Patients taking oral terbinafine should have liver function tests performed prior to treatment to reduce the risk of liver injury.

Mechanism of action :

Terbinafine inhibits the enzyme squalene monooxygenase (also called squalene epoxidase), preventing the conversion of squalene to 2,3-oxydosqualene, a step in the synthesis of ergosterol.This inhibition leads to decreased ergosterol, which would normally be incorporated into the cell wall, and accumulation of squalene.

Storage :

  • Do not store above 25°C store in the original package.
  • Keep blister in the outer carton.
Terbitop Contains

Terbinafine Tablets USP

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