RABEST- DSR capsule is an anti ulcer drug .It belongs to category of proton pump inhibitor (PPI).This is indicated for the treatment of GERD (Gastro- esophageal reflux disease). Rabest-D is useful for reducing the tendency of vomiting and nausea. Rabest-D is the combination of two pharmaceutical ingredients which are Domperidone and Rabeprazole. It helps to speed up the passing of food that you intake from your stomach to your intestine and also useful to treat ulcers like peptic and duodenal ulcers.
Composition of RABEST- DSR capsule:
It is the combination of salts of Rabeprazole 30 mg and Domperidone 20 mg. It acts as antacid and anti- emetic drug.
Mode of action of Rabeprazole:
Chemical formula: C18H21N3O3, Half life: 1-2 hrs
It is a PPI that reduces the amount of acid production in stomach.It acts by inhibiting the H+,K+ ATP ase pump of the gastric parietal cells in stomach lines and belongs to class of organic compounds known as Sulfinylbezimidazoles.
Indications of Rabeprazole:
Rabeprazole used in treating ulcers of stomach and duodenum, ulcerative gastroesophageal reflux disease and zollinger- ellisons syndrome. It was also used with antibiotics to treat Helicobacter pylori infections which is main cause of many ulcer formations in stomach and intestine.
Adults – 20mg daily for 4-8 weeks in case of GERD.
Adults – 20 mg daily for 4 weeks in case of heart burn.
60 mg daily in case of zollinger- Ellisons syndrome and 100mg/day and 60mg twice a day.
Mode of action of Domperidone:
Chemical Formula: C22H24Cl N5O2, Half life: 7 Hrs
It is composed with 30 mg of active pharmaceutical ingredient of Domperidone and with non medical ingredients like lactose and cornstarch, microcrystalline cellulose, povidone, magnesium stearate, sodium docusate 85%-sodium benzoate 15%, croscarmellose sodium, polyethylene glycol, hydroxypropyl methylcellulose, hydroxypropyl cellulose, and titanium dioxide. Domperidone is an Anti-sickness medicine and which help you to stop feeling and being sick. Its treat stomach pain and increases milk suuply in lactation mothers. However, prescription is required if your having trouble in breast feeding.
Domperidone is an Anti- dopaminergic drug used orally, rectally/IV to reduce nausea and vomiting.It reversibly raises serum prolactin levels that may lead to galactorrhrea and gynaecomastia, abdominal cramps, pain, dry mouth, Diarrohoe, headache, migrane and rashes.
Indications of Domperidone:
- Domperidone is used to treat GIT disorders by slowing down the movement in GIT associated with Diabetes and Gastritis.
- It helps to reduce stomach problems like nausea and Vomiting.
Is there any Adverse effects:
Yes, every drug has side effects. RABEST-DSR capsules shows some adverse effects:
Abdominal cramps, diarrhoea, breast pain, dry mouth , head ache, breast milk flowing from nipple, dizziness and fainting.
What are the Drugs interact with RABEST-DSR?
ALfuzosin Amantidine, Amiodarone, Anti- Histamines like cetrizine, Doxylamine and Chloroquines.
Is RABEST- DSR works effectively?
RABEST- DSR capsules are proton pump inhibitors which belongs to category of antacid and anti emetics. The proton pumps are present in stomach cells which are responsible for secretion of stomach acids.
The role of Rabeprazole binds to proton pumps in gastric parietal cells, that block acid secretions. Domperidone is the chief pharmaceutical ingredient which shows it action by reducing nausea and vomiting by reducing the motility of stomach and intestines. There by it blocks the back reflex of acids.
Is RABEST – DSR capsule is safe in pregnancy and breast feeding?
The pharmaceutical ingredients in RABEST – DSR might harm to unborn baby.It should not taken by pregnant women, in case of emergency consult your physician and inform that your are pregnant or planning to have a baby. This medication may passes into breast milk and affects baby health. However consult a physician before taking.
General warnings before taking RABEST-DSR capsules?
Talk your doctor if –
You have watery diarrhoea, black stools, stomach tumours.
History of fractures, kidney impairments, CVS disorders like palpitations and difficult in breathing.
Whether you are with rare hereditary problems of Galactose intolerance.
Renal impairments – Elimination half life will be prolonged in severe renal failure and bleeding in stomach and intestine.
Cardiovascular system- Having a congenital QT interval prolongation.
Contraindicated who are under the following medications:
Patients who are under the following medications should not take RABEST- DSR:
- Anti-viral drugs include Rilpivirine, Atazanavir
- Amiodarone, Haloperidole
- Antibiotics like Digoxin which was used in heart failure
What should do if you missed a dose?
If you missed a dose take it as soon as you remember. Do not take double dose to compensate missed dose. It may leads to increased side effects.
What happen if you take Over dose?
If RABEST – DSR is overdosed it causes some side effects like confusion, sleepiness and fits. In case of emergency consult your physician immediately or nearest hospital.
What are side effects occurs after taking RABEST- DSR?
- Abnormal heart rhythm.
- Abdominal pain.
- Flatulence and dryness of
- Breast enlargement, rashes and Akathesia.
Directions to use:
Take this medicine with sufficient amount of water ,do not chew or crush the capsule since it may lead to high frequency of occurring side effects due to sudden release of ingredients.
Storage conditions and Disposal:
- It should be stored at 15-30 o
- Keep way from the moisture and should be stored in tight containers.
- Keep way from the children and pets.
- Ensure the medications should be disposed in special way like medication take back programme.