Oxizen – 25

Oxizen – 25

225.00 900.00

Hydroxyzine is used to treat itching caused by allergies. It is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Since hydroxyzine also reduces activity in the central nervous system, it can be used as a sedative to treat anxiety and tension. Hydroxyzine may also be used short-term to treat anxiety & works by decreasing the activity in brain, thereby helps you feel sleepy/relaxed before and after surgery.

Category:

Composition: Hydroxyzine Hydrochloride 25 mg Tablets

Hydroxyzine is used to treat itching caused by allergies. It is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Since hydroxyzine also reduces activity in the central nervous system, it can be used as a sedative to treat anxiety and tension. Hydroxyzine may also be used short-term to treat anxiety & works by decreasing the activity in brain, thereby helps you feel sleepy/relaxed before and after surgery. It may be used alone or with other medications.This medicine is specifically used with other medicines to induce sleep before surgery.

Indications

For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested.

Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus.

As a sedative when used as premedication and following general anesthesia, hydroxyzine may potentiate meperidine and barbiturates, so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug. Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent.

The effectiveness of hydroxyzine as an antianxiety agent for long term use, that is more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient.

Contraindications

Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit, induced fetal abnormalities in the rat and mouse at doses substantially above the human therapeutic range. Clinical data in human beings are inadequate to establish safety in early pregnancy. Until such data are available, hydroxyzine is contraindicated in early pregnancy.

Hydroxyzine is contraindicated for patients who have shown a previous hypersensitivity to it.

Side Effects

Oxizen – 25 may cause serious side effects including:

  • mood changes,
  • restlessness,
  • confusion,
  • hallucinations,
  • shaking,
  • difficulty urinating, and
  • fast or irregular heartbeat

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects ofOxizen – 25 include:

  • drowsiness,
  • dizziness,
  • blurred vision,
  • constipation, and
  • dry mouth

Tell your doctor if you have any side effect that bothers you or that does not go away.

Mechanism of Action

Hydroxyzine competes with histamine for H1-receptor sites on the effector cell surface. Blockade of H1-receptors also suppresses the formation of edema, flare, and pruritus that result from histaminic activity. The sedative properties of hydroxyzine occur at the subcortical level of the CNS, and, as mentioned above, this effect may be dose-related. Hydroxyzine has some antiemetic actions secondary to its central anticholinergic actions. Hydroxyzine also demonstrates antiarrhythmic, analgesic, local anesthetic, and skeletal muscle relaxant properties as well as bronchodilatory and mild antisecretory effects. Although antihistamines possess intrinsic analgesic properties (perhaps secondary to interfering with nociception), they should not be considered potent analgesics.

Pharmacology

Hydroxyzine blocks the activity of histamine to relieve allergic symptoms such as pruritus.Activity at off-targets also allows for its use as a sedative anxiolytic and an antiemetic in certain disease states.

Hydroxyzine is relatively fast-acting, with an onset of effect that occurs between 15 and 60 minutes and a duration of action between 4-6 hours. Hydroxyzine may potentiate the effects of central nervous system (CNS) depressants following general anesthesia – patients maintained on hydroxyzine should receive reduced doses of any CNS depressants required. Hydroxyzine is reported to prolong the QT/QTc interval based on postmarketing reports of rare events of Torsade de Pointes, cardiac arrest, and sudden death, and should be used with caution in patients with an increased baseline risk for QTc prolongation.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze liquid forms of this medication. Keep all medications away from children and pets.

Oxizen – 25 Contains

Hydroxyzine Hydrochloride 25 mg