Losa-50 – Description
Losa – 50 is a composition of Losartan Potassium (25 mg)
Losartan Potassium – Overview
Losartan belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease. Losartan is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.
Losartan potassium works by relaxing the blood vessels to allow the blood to flow more efficiently, which reduces a person’s blood pressure. The United States Food and Drug Administration (FDA) approved the drug in 1995 to treat hypertension.
Benefits of Losartan Potassium
Losartan Potassium is used for controlling hypertension; decreasing stroke risk; reducing proteinuria, which is an abnormal amount of protein in the urine that suggests kidney damage and slowing diabetic nephropathy.
The usual starting dose of Losartan potassium is 50 mg once daily. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure. A starting dose of 25 mg is recommended for patients with possible intravascular depletion (e.g., on diuretic therapy). The usual recommended starting dose is 0.7 mg per kg once daily (up to 50 mg total). Dosage should be adjusted according to blood pressure response.
Losartan potassium is not recommended in pediatric patients less than 6 years of age or in pediatric patients with estimated glomerular filtration rate less than 30 ml/min/1.73 m2
People who cannot/restricted to used Losartan Potassium
Losartan Potassium can affect a fetus. They may affect the kidney function of the fetus and increase their risk of illness or death. People taking losartan should speak to their doctor immediately after confirming the pregnancy, as they will likely need to stop taking the medication until the baby is born. The FDA advice that people who breast-feed should not take losartan, as the medication passes into the breast milk.
Interaction of Losartan Potassium with other drugs
Co administration of losartan with other drugs that raise serum potassium levels may result in hyperkalemia. Monitor serum potassium in such patients.
Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists. Monitor serum lithium levels during concomitant use.
In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists (including losartan) may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving losartan and NSAID therapy.
Do not co administer aliskiren with Losartan potassium in patients with diabetes. Avoid use of aliskiren with Losartan potassium in patients with renal impairment (GFR <60 ml/min).