FenoFit (Micronized Fenofibrate 200mg) – 10 Tablet(s) in a Strip

FenoFit (Micronized Fenofibrate 200mg) – 10 Tablet(s) in a Strip

10.00

Category – immune tablet
Purpose – metabolized in the liver and excreted mainly in the urine.
Salt Composition – Micronized Fenofibrate 200mg
Form –  Tablet.
1 Quantity –  10 Tablet(s) in a Strip

The micronized form of fenofibrate is more rapidly and completely absorbed than the standard formulation. A 67-mg micronized capsule of fenofibrate is the bioequivalent of a 100-mg, non-micronized tablet. So micronized form of fenofibrate is much more effective than simple fenofibrate and is highly preferred by Medical practitioners. Taking the drug with food increases the rate of absorption, and plasma concentration reaches a peak in six to eight hours. Fenofibrate has a half-life of approximately 20 hours and is metabolized in the liver and excreted mainly in the urine.

  • 10 Tablets
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FenoFit – Description

FenoFit is a composition of Micronized Fenofibrate which is available in the capsule form

Fenofibrate – What is this medicine?

FENOFIBRATE (fen oh FYE brate) a member of the fibrate class of lipid-modifying drugs can help lower blood fats (triglyceride) and cholesterol for people who are at risk of getting inflammation of the pancreas from having very high amounts of fats in their blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). This medicine is only for patients whose blood fats are not controlled by diet.

Fenofibrate and micronized fenofibrate

The micronized form of fenofibrate is more rapidly and completely absorbed than the standard formulation. A 67-mg micronized capsule of fenofibrate is the bioequivalent of a 100-mg, non-micronized tablet. So micronized form of fenofibrate is much more effective than simple fenofibrate and is highly preferred by Medical practitioners. Taking the drug with food increases the rate of absorption, and plasma concentration reaches a peak in six to eight hours. Fenofibrate has a half-life of approximately 20 hours and is metabolized in the liver and excreted mainly in the urine.

Mechanism of Fenofibrate

The active metabolite of fenofibrate is fenofibric acid. The pharmacological effects of fenofibric acid in both animals and humans have been extensively studied through oral administration of fenofibrate.

The lipid-modifying effects of fenofibric acid seen in clinical practice have been explained in vivo in transgenic mice and in vitro in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor α (PPARα). Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting decrease in triglycerides produces an alteration in the size and composition of LDL from small, dense particles to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Activation of PPARα also induces an increase in the synthesis of apolipoproteins AI, AII and HDL cholesterol. Fenofibrate also reduces serum uric acid levels in hyperuricemic and normal individuals by increasing the urinary excretion of uric acid.

Uses of Fenofibrate

Fenofibrate is a potent triglyceride-lowering and high-density lipoprotein cholesterol-raising agent and has a variable effect on low-density lipoprotein cholesterol. Fenofibrate administration also leads to a modified, less atherogenic low-density lipoprotein profile, with a consistent effect toward increased low-density lipoprotein particle size and a reduction in the low-density lipoprotein particle density. Fenofibrate is used to improve cholesterol levels in three types of cholesterol problems: Mixed dyslipidemia, severe hypertriglyceridemia, and Primary hypercholesterolemia. Fenofibrate also helps increase levels of HDL (good) cholesterol.

Restriction to usage of Fenofibrate in certain people

Fenofibrate should not be used in nursing mothers. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Safety and effectiveness have not been established in pediatric patients. Fenofibrate is substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Since elderly patients have a higher incidence of renal impairment, the dose selection for the elderly should be made on the basis of renal function. The use of fenofibrate should be avoided in patients who have severe renal impairment. Patients with preexisting gallbladder disease should avoid using fenofibrate.

Storage

Keep out of the reach of children; Do not keep outdated medicine or medicine no longer needed; Ask your healthcare professional how you should dispose of any medicine you do not use; Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light; Store at 25°C; excursions permitted at 15° to 30°C (59° to 86°F) Keep from freezing; Keep FenoFit tablets in its original container. Protect from heat, light, and moisture.

Additional Information

Pack

10 Tablets

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