AntiMa (6 Strips in a Pack)

AntiMa (6 Strips in a Pack)

274.00 1,730.00

AntiMa (Artemether 80mg + Lumefantrine 480mg) – 6 Strips

Composition: Artemether 80mg + Lumefantrine 480mg Tablets

AntiMa belongs to a class of drugs called Antimalarials. AntiMa contain a fixed combination of 2 antimalarial active ingredients, artemether, an artemisinin derivative, and lumefantrine.Both components are blood schizontocides. The chemical name of artemether is (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j]-1,2- benzodioxepine.It is used to treat malaria. These medicines work by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.

AntiMamay be used alone or with other medications.


  • Treatment of uncomplicated falciparum malaria
  • Treatment of uncomplicated malaria due to other Plasmodium species, when chloroquine cannot be used
  • Completion treatment following parenteral therapy for severe malaria


The use of AntiMaTablet is considered to be harmful for patients with a known hypersensitivity to any of the active or inactive ingredients of the medicine. Caution is advised in patients with cases of severe malaria and in the first trimester of pregnancy.

  • May cause: headache, dizziness and gastrointestinal disturbances.
  • Administer with caution to patients taking drugs that prolong the QT interval: amiodarone, other antimalarials, antipsychotics, fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.
  • If the patient vomits within 30 minutes after administration: re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose.

Side Effects

AntiMamay cause serious side effects including:

  • worsening malaria symptoms,
  • severe vomiting,
  • loss of appetite,
  • unable to eat,
  • fast or pounding heartbeats,
  • light-headedness, and
  • skin rash, no matter how mild

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of AntiMa include:

  • headache,
  • dizziness,
  • fever,
  • cough,
  • feeling weak or tired,
  • muscle pain,
  • tenderness,
  • weakness,
  • joint pain,
  • vomiting, and
  • loss of appetite

Tell the doctor if you have any side effect that bothers you or that does not go away.


In the body, artemether is metabolized into the active metabolite metabolite dihydroartemisinin. The drug works against the erythrocytic stages of P. falciparum by inhibiting nucleic acid and protein synthesis. Artemether is administered in combination with lumefantrine for improved efficacy. Artemether has a rapid onset of action and is rapidly cleared from the body. It is thought that artemether provides rapid symptomatic relief by reducing the number of malarial parasites. Lumefantrine has a much longer half-life and is believed to clear residual parasites.

Mechanism of Action

Involves an interaction with ferriprotoporphyrin IX (“heme”), or ferrous ions, in the acidic parasite food vacuole, which results in the generation of cytotoxic radical species.

The generally accepted mechanism of action of peroxide antimalarials involves interaction of the peroxide-containing drug with heme, a haemoglobin degradation by-product, derived from proteolysis of haemoglobin. This interaction is believed to result in the formation of a range of potentially toxic oxygen and carbon-centred radicals.


Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

AntiMa Contains

Artemether 80mg
Lumefantrine 480mg